BRAF (gene)

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V-raf murine sarcoma viral oncogene homolog B1
PDB rendering based on 1uwh.
Available structures: 1uwh, 1uwj, 2fb8
Identifiers
Symbols BRAF; B-raf 1; BRAF1; MGC126806; MGC138284; RAFB1
External IDs OMIM: 164757 HomoloGene: 3197
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 673 n/a
Ensembl ENSG00000157764 n/a
Uniprot P15056 n/a
Refseq NM_004333 (mRNA)
NP_004324 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 7: 140.08 - 140.27 Mb n/a
Pubmed search [4] n/a

V-raf murine sarcoma viral oncogene homolog B1, also known as BRAF, is a human gene.

The BRAF gene makes a protein called B-RAF, which is involved in sending signals in cells and in cell growth. This gene may be mutated1 (changed) in many types of cancer, which causes a change in the B-RAF protein. This can increase the growth and spread of cancer cells.

Some pharmaceutical firms are doing basic research to develop specific inhibitors of B-raf protein for anticancer use.23


References

  1. ^ [1]Davies H, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949–954.
  2. ^ [2]King AJ et al. (2006) Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 66(23):11100-5.
  3. ^ [3]Tsai, J et al. (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc.Natl.Acad.Sci.USA 105: 3041-3046

Further reading

  • Sithanandam G, Kolch W, Duh FM, Rapp UR (1991). "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies". Oncogene 5 (12): 1775–80. PMID 2284096. 
  • Garnett MJ, Marais R (2004). "Guilty as charged: B-RAF is a human oncogene". Cancer Cell 6 (4): 313–9. doi:10.1016/j.ccr.2004.09.022. PMID 15488754. 
  • Quiros RM, Ding HG, Gattuso P, et al. (2005). "Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations". Cancer 103 (11): 2261–8. doi:10.1002/cncr.21073. PMID 15880523. 
  • Karbowniczek M, Henske EP (2006). "The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?". Ann. N. Y. Acad. Sci. 1059: 168–73. doi:10.1196/annals.1339.045. PMID 16382052. 
  • Ciampi R, Nikiforov YE (2007). "RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis". Endocrinology 148 (3): 936–41. doi:10.1210/en.2006-0921. PMID 16946010. 
  • Espinosa AV, Porchia L, Ringel MD (2007). "Targeting BRAF in thyroid cancer". Br. J. Cancer 96 (1): 16–20. doi:10.1038/sj.bjc.6603520. PMID 17179987. 

External links

  • "BRAF gene". NCI Dictionary of Cancer Terms. Retrieved on 2007-11-25.
 This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.
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This article includes text from the U.S. National Cancer Institute's public domain Dictionary of Cancer Terms

Wikipedia content modification information:

  • This page was last modified on 3 December 2008, at 17:47.

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