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Benzydamine
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| Systematic (IUPAC) name | |
| 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine | |
| Identifiers | |
| CAS number | |
| ATC code | A01 G02CC03 M01AX07 M02AA05 |
| PubChem | |
| Chemical data | |
| Formula | C19H24N3O |
| Mol. mass | 282 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.[1]
It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) is virtually free of any adverse systemic effects.
It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.
Contents |
Availability
It is available in a mouth wash named Tantum Verde across Europe. In the UK it is sold by 3M under the trade name Difflam, as Difflam Spray, Difflam Oral Rinse and Difflam Cream. Its high cost (about £7 a bottle) makes it less attractive than the cheaper method of gargling aspirin. In Australia it is available from 3M as Difflam-C Alcohol & Colour Free Solution, Difflam 3% Gel, Difflam Extra Strength Gel 5%, Difflam-C Solution, Difflam Solution (including Difflam Throat Spray), Difflam Cream and Difflam Lozenges.[2] It is sold in eastern Europe without prescription as Tantum Rosa - a vaginal antiseptic and antiinflammatory, containing 0.14 g of benzydamine hydrochloride to be reconstitued with clean water to a 0.1% (1 mg/mL) solution for vaginal enema/instillation. In Brazil it is sold by prescription under the name "Benflogin", with each box containing 20 pills (50mg each). In Pakistan it is sold by prescription under the name Tantum Capsule (50mg). It is available in a cream and gel named Tantum Fort across Egypt by EIPICo. It is available with prescription as a mouthwash named Novo-Benzydamine (Novopharm) in Canada.
Indications
Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.
Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.
Contraindications
There are no contraindications to the use of Benzydamine except for known hypersensitivity.
Side effects
Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine may be abused recreationally.[3] In oral dosages of 500 mg to 3000 mg it is a deliriant and CNS stimulant, popular in Poland and Brazil. In Brazil it is very popular and many people use it for recreational purposes. A person in a benzydamine trip may experience a feeling of well-being, euphoria and in higher doses will hallucinate, paranoia, dry mouth and convulsions may also be experienced. The trip can last up to 8 hours, after that the user becomes tired and quiet, but sleeping is almost impossible. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic. [3]
Footnotes
- ^ Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 1995 Feb;61(2):127-34.
- ^ Material Safety Data Sheets for Difflam varieties sold in Australia
- ^ a b Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clinical Toxicology (Philadelphia, Pa). 2007;45(2):198-9.
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Wikipedia content modification information:
- This page was last modified on 25 August 2008, at 17:21.
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