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| Bernard Katz | |
| Born | 26 March 1911 Leipzig, Germany. |
|---|---|
| Died | 20 April 2003 (Age 92) London, England. |
| Fields | Neurophysiology |
| Institutions | University College London. Sydney Hospital. |
| Alma mater | University of Leipzig |
| Known for | Neurophysiology of the synapse |
| Notable awards | Nobel Prize in Physiology or Medicine (1970) |
Sir Bernard Katz, FRS (26 March 1911 – 20 April 2003) was a German-born biophysicist, noted for his work on nerve biochemistry. He shared the Nobel Prize in physiology or medicine in 1970 with Julius Axelrod and Ulf von Euler. He was knighted in 1970.
Born in Leipzig to a Jewish family, Germany, he was educated at the Albert Gymnasium in that city from 1921 to 1929 and went on to study medicine at the University of Leipzig. He graduated in 1934 and fled to Britain in February 1935, the rise of Hitler having made his Russian-Jewish heritage dangerous. He went to work at University College London, initially under the tutelage of Archibald Vivian Hill. He finished his PhD in 1938 and won a Carnegie Fellowship to study with John Carew Eccles at Sydney Hospital. He was naturalised in 1941 and joined the Royal Australian Air Force in 1942. He spent the war in the Pacific as a radar officer. He married Marguerite Penly in 1945 and returned to UCL as an assistant director in 1946. Back in England he also worked with the 1963 Nobel prize winners Alan Hodgkin and Andrew Huxley. Katz was made a professor at UCL in 1952 and head of biophysics, he was also elected to the Royal Society. He stayed as head of biophysics until 1978 when he became emeritus professor. At the age of 92, he died in London on 20 April 2003.
His research uncovered fundamental properties of synapses, the junctions across which nerve cells signal to each other and to other types of cells. By the 1950s, he was studying the biochemistry and action of acetylcholine, a signalling molecule with which synapses linking "motor nerves" to muscles stimulate contraction. Katz won the Nobel for his discovery that neurotransmitter release at synapses is "quantal"--that is, that at any particular synapse the amount of neurotransmitter released is never less than a certain amount, and if more is always an integral number times this amount. This circumstance arises, scientists now know, because, prior to their release into the synaptic gap, transmitter molecules reside in like-sized subcellular packages known as synaptic vesicles (more at exocytosis).
Katz's work had immediate influence on the study of organophosphates and organochlorines, the basis of new post-war study for nerve agents and pesticides, as he determined that the complex enzyme cycle was easily disrupted.
References
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Further reading
- "School of Katz" (PDF). Quarterly Journal of Experimental Biology. 1990, http://ep.physoc.org/cgi/issue_pdf/frontmatter_pdf/74/1.pdf.
External links
- Sir Bernard Katz Biography. Nobel Foundation
- Guardian Obituary
- Australian Neuroscience Society Obituary
- Sabbatini, R.M.E.: Neurons and synapses. The history of its discovery IV. Chemical transmission. Brain & Mind, 2004.
- Physiology Online, PhysiologyNews, Issue 52, Autumn 2003
- Bernard Katz: "An autobiographical sketch"
- König-Albert-Gymnasium Leipzig
| Persondata | |
|---|---|
| NAME | Katz, Bernard |
| ALTERNATIVE NAMES | |
| SHORT DESCRIPTION | Nobel Prize - Neurophysiology |
| DATE OF BIRTH | 26 March 1911 |
| PLACE OF BIRTH | Leipzig, Germany. |
| DATE OF DEATH | 20 April 2003 |
| PLACE OF DEATH | London, England. |
Wikipedia content modification information:
- This page was last modified on 21 October 2008, at 10:57.
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