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| Identifiers | |
| Symbol | GBA |
| Alt. Symbols | GLUC |
| Entrez | 2629 |
| HUGO | 4177 |
| OMIM | 606463 |
| RefSeq | NM_000157 |
| UniProt | P04062 |
| Other data | |
| EC number | 3.2.1.21 |
| Locus | Chr. 1 q22 |
|
glucosidase, beta, acid 3 (cytosolic)
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| Identifiers | |
| Symbol | GBA3 |
| Entrez | 57733 |
| HUGO | 19069 |
| OMIM | 606619 |
| RefSeq | NM_020973 |
| UniProt | Q9H227 |
| Other data | |
| EC number | 3.2.1.21 |
| Locus | Chr. 4 p15.31 |
Beta-glucosidase is a glucosidase enzyme which acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.
Cellulose is largely composed of polymers of beta-bond linked glucose molecules, and beta-glucosidases are required by organisms (some fungi, bacteria, termites) that can consume it.
Lysozyme, an enzyme secreted in tears to prevent bacterial infection of the eye, is also a beta-glucosidase that cleaves β1->4 bonds between N-acetylglucosamine and N-acetylmuramic acid sugars within the peptidoglycan cell walls of gram-negative bacteria.
External links
References
- Nelson DL, Cox MM. "Lehninger: Principles of Biochemistry" 2000 p 306-308
- GO-database listing 'GO:0016162 cellulose 1,4-beta-cellobiosidase activity'
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- This page was last modified on 2 September 2008, at 23:53.
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