Welcome to the MedLibrary.org Wikipedia Supplement on Bioinformatic Harvester -- Please Click to Return to Front Page

The Bioinformatic-Harvester is a bioinformatic meta search engine at KIT Karlsruhe Institute of Technology for genes and protein-associated information. Harvester currently works for human, mouse, rat, zebrafish, drosophila and arabidopsis thaliana based information. Harvester cross-links >28 popular bioinformatic resources and allows cross searches. A ranking system similar to Google pagerank sorts the search results and displays the more relevant information. Harvester serves 10.000s of pages every day to scientists and physicians.

Contents 1 How Harvester works 2 Harvester collects several types of information 2.1 Text based information 2.2 Databases rich in graphical elements 2.3 "linkouts" 3 What one can find 4 See also 5 Literature 6 External links

How Harvester works

Harvester collects information from protein and gene databases along with information from so called "prediction servers." Prediction server e.g provide online sequence analysis for a single protein. Harvesters search index is based on the IPI and UniProt protein information collection. The collections consists of:

• ~68.000 human, ~53.000 mouse, ~42.000 rat, ~51.000 zebrafish, ~35.000 arabidopsis and ~33.000 drosophila protein pages, which are curated and updated on a regular basis.

Harvester collects several types of information

Text based information

...from the following databases:

• UniProt, world largest protein database
• SOURCE, convenient gene information overview
• Simple Modular Architecture Research Tool (SMART),
• SOSUI, predicts transmembrane domains
• PSORT, predicts protein localisation
• HomoloGene, compares proteins from different species
• gfp-cdna, protein localisation with fluorescence microscopy
• International Protein Index (IPI).

Databases rich in graphical elements

...are not collected, but crosslinked via iframes. Iframes are transparent windows within a HTML pages. The iframe windows allows up-to-date viewing of the "iframed," linked databases. Several such iframes are combined on a Harvester protein page. This method allows convenient comparison of information from several databases.

• NCBI-BLAST, an algorithm for comparing biological sequences from the NCBI.
• Ensembl, automatic gene annotation by the EMBL-EBI and Sanger-Institute
• FlyBase is a database of model organism Drosophila melanogaster.
• GoPubMed is a knowledge-based search engine for biomedical texts.
• iHOP, information hyperlinked over proteins via gene/protein synonyms
• Mendelian Inheritance in Man project catalogues all the known diseases.
• RZPD, German resources Center for genome research in Berlin/Heidelberg.
• STRING, Search Tool for the Retrieval of Interacting Genes/Proteins by the EMBL.
• Zebrafish Information Network.
• LOCATE subcellular localization database (mouse).

"linkouts"

• Genome browser, working draft assemblies for genomes UCSC
• Google Scholar
• Mitocheck
• PolyMeta, meta search engine for Google, Yahoo, MSN, Ask, Exalead, AllTheWeb, GigaBlast

What one can find

Harvester allows a combination of different search terms and single words.

Search Examples:

• Gene-name: "golga3"
• Gene-alias: "ADAP-S ADAS ADHAPS ADPS" (one gene name is sufficient)
• Gene-Ontologies: "Enzyme linked receptor protein signaling pathway"
• Unigene-Cluster: "Hs.449360"

• Go-annotation: "intra-Golgi transport"
• Molecular function: "protein kinase binding"
• Protein: "Q9NPD3"
• Protein domain: "SH2 sar"
• Protein Localisation: "endoplasmic reticulum"

• Chromosome: "2q31"
• Disease relevant: use the word "diseaselink"
• Combinations: "golgi diseaselink" (finds all golgi proteins associated with a disease)
• mRNA: "AL136897"

• Word: "Cancer"
• Comment: "highly expressed in heart"
• Author: "Merkel, Schmidt"
• Publication or project: "cDNA sequencing project"

v • d • e Databases supported by Bioinformatic Harvester NCBI-BLAST  · CDD  · Ensembl  · Entrez  · Flybase  · Flymine  · GFP-cDNA  · Genome browser  · GeneCard  · Google Scholar  · GoPubMed  · HomoloGene  · iHOP  · IPI  · OMIM  · MGI  · Mitocheck  · PSORT  · PolyMeta  · RGD  · UniProt  · SOURCE  · SOSUI  · RZPD  · Sciencenet  · STRING  · SMART  · TAIR  · WikiProfessional  · ZFIN

See also

• Biological databases
• Entrez
• European Bioinformatics Institute
• Human Protein Reference Database
• Metadata
• Sequence profiling tool

Literature

• Liebel,U., & Kindler,B.,Pepperkok,R. (2004) 'Harvester': a fast meta search engine of human protein resources. Bioinformatics. 2004 Aug 12;20(12):1962-3. Epub 2004 Feb 26.[1]

• Liebel,U., & Kindler,B.,Pepperkok,R. (2004) Bioinformatic "Harvester": a search engine for genome-wide human, mouse, and rat protein resources. Methods Enzymol. 2005;404:19-26[2]

External links

• http://harvester.fzk.de Bioinformatic Harvester III at KIT Karlsruhe Institute of Technology
• Liebel-Lab at KIT

Wikipedia content modification information:

• This page was last modified on 1 September 2008, at 20:47.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Bioinformatic Harvester".

The URL for this specific entry is:

• http://medlibrary.org/medwiki/Bioinformatic_Harvester

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.