Brallobarbital

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Brallobarbital
Systematic (IUPAC) name
5-(2-bromoprop-2-enyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Identifiers
CAS number 561-86-4
ATC code  ?
PubChem 68416
Chemical data
Formula C10H11BrN2O3 
Mol. mass 287.11 g/mol
Synonyms Brallobarbital, Vesparax
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Brallobarbital is a barbiturate derivative invented in 1964. It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine.[1] The long half-life of this combination of drugs tended to cause a hangover effect the next day,[2] and Vesparax fell into disuse once newer drugs with less side effects had been developed.[3]

References

  1. ^ Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)
  2. ^ Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.
  3. ^ Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.
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Barbiturates (N01AF, N03AA, N05CA)

Allobarbital • Alphenal • Amobarbital • Aprobarbital • Barbexaclone • Barbital • Brallobarbital • Brophebarbital • Bucolome • Butabarbital • Butalbital • Butobarbital • Butallylonal • Crotylbarbital • Cyclobarbital • Cyclopal • Enallylpropymal • Ethallobarbital • Febarbamate • Heptabarbital • Hexethal • Hexobarbital • Mephobarbital • Metharbital • Methohexital • Methylphenobarbital • Narcobarbital • Nealbarbital • Pentobarbital • Phenobarbital • Phetharbital • Prazitone • Probarbital • Propallylonal • Proxibarbal • Proxibarbital • Reposal • Secbutabarbital • Secobarbital • Sigmodal • Spirobarbital • Talbutal • Thialbarbital • Thiamylal • Thiobarbital • Thiobutabarbital • Thiopental • Valofane • Vinbarbital • Vinylbital
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Psycholeptics: hypnotics and sedatives (N05C)
GABAA receptor
Alpha-2 adrenergic receptor
Melatonin receptor
Histamine receptor &
Acetylcholine receptor
GABAB receptor / GHB receptor
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Wikipedia content modification information:

  • This page was last modified on 9 February 2008, at 23:18.

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