Bretylium

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Bretylium
Systematic (IUPAC) name
(2-bromophenyl)methyl-ethyl-dimethyl-ammonium
Identifiers
CAS number 59-41-6
ATC code C01BD02
PubChem 2431
DrugBank APRD00830
Chemical data
Formula C11H17BrN+
Mol. mass 243.163 g/mol
Pharmacokinetic data
Bioavailability NA
Protein binding NA
Metabolism None
Half life 7-8 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)
Legal status

℞-only(US)
Routes IV, IM

Bretylium (also bretylium tosylate) blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, & other specialties for the acute management of ventricular tachycardia & ventricular fibrillation. It is contraindicated in patients with AV (atrioventricular) heart block or digoxin toxicity. Bretylium is only used in an ICU setting and should not be used elsewhere due to its dramatic actions and its predominant side effect of hypotension.

Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Antiarrhythmic agents (C01B)
class I
(sodium channel)
class Ia
class Ib
class Ic
class II
(beta blockers)
class III
(potassium channel)
Amiodarone • Bretylium tosylate • Bunaftine • Dofetilide • Ibutilide • Nifekalant • Sotalol
class IV
(calcium channel blockers)
class V
(other)



Bretylium is no longer taught in ACLS.

Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 23:29.

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