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Smyth came to light as a singer at a young age; as a boy soprano he found himself in demand in many churches in Dublin. He studied singing at the Leinster School of Music & Drama,. He joined his local drama society in his late teens. By his early twenties he was playing many amateur leading parts, Smyth quickly turned professional.
As an actor,and singer he appeared in productions ranging from Oklahoma!, Hello, Dolly!, Follies, Sweeney Todd to The Rocky Horror Show. Drama work includes Glengarry Glen Ross at the Andrews Lane Theatre, Dublin, Sive and The Cuchulain Cycle. Smyth's first musical West End performance was in 1999 when he was asked to play the role of Matthew Mugg alongside Phillip Schofield in Leslie Bricusse's stage adaptation of the film musical Doctor Dolittle directed by Steven Pimlott. He trained in London with top voice coach Mary Hammond and Smyth's performance in the show brought much critical acclaim. The show ran for over 500 performances in London's largest theatre. After many offers from various musicals he decided to take up an offer to work on television and return to Ireland.
His hit show, It's Not the Answer, ran for four years on the national broadcaster's channel RTÉ and spent most of that time in the top five ratings. While working on the show he was asked to open and close the 2000 New Year's Eve show on RTÉ. He has also appeared in the Variety Club with Tony Bennett and Julie Andrews. He has also appeared with Andy Williams and is also a frequent guest on The Lyrics Board game show also on RTÉ with Eurovision Song Contest winner Paul Harrington and Kyron Bourke. He has also worked and performed with Hazel O'Connor, Millicent Martin, and Lorna Luft. He has also performed for Prince Charles at the London Palladium and he has also performed at the Burj Al Arab in Dubai. 2008 saw Bryan return to performing.Bryan is well known for his charity work in particular with Variety the childrens charity. In 2012 Bryan toured the USA as leading male vocalist in an Irish themed show.