Bumetanide

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Bumetanide
Systematic (IUPAC) name
3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid
Identifiers
CAS number 28395-03-1
ATC code C03CA02
PubChem 2471
DrugBank APRD00294
Chemical data
Formula C17H20N2O5S 
Mol. mass 364.417 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability almost complete
Protein binding 97%
Metabolism hepatic
Half life 60-90 minutes
Excretion renal
Therapeutic considerations
Pregnancy cat.

B3(AU) C(US)
Legal status

Prescription Only (S4)(AU) POM(UK) ℞-only(US)
Routes oral

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche with the brand name Bumex. The main difference between the two substances is in bioavailability. Furosemide is incompletely absorbed in the intestine (40%), and there is substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.

Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).

External links

Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
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Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)
Vasodilators
Other antihypertensives
Low ceiling diuretics
High ceiling diuretics
Potassium-sparing diuretics

Wikipedia content modification information:

  • This page was last modified on 21 May 2008, at 20:48.

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