Buserelin

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Buserelin
Systematic (IUPAC) name
 ?
Identifiers
CAS number 57982-77-1
ATC code L02AE01
PubChem 50225
DrugBank HMDB03170
Chemical data
Formula C62H90N16O15 
Mol. mass 1299.48 g/mol
Synonyms D-Ser(Tbu)6EA10LHRH
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 72 to 80 minutes
Excretion Renal
Therapeutic considerations
Pregnancy cat.

X
Legal status

℞-only
Routes implant, intranasal

Buserelin is a Gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.

It is normally delivered via a nasal spray but is also available as an injection.

Buserelin acetate is marketed by Sanofi-Aventis under the brand name Suprefact.

Generic form of Buserelin is produced by CinnaGen under the brand name CinnaFact

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Sex hormones and related agents (primarily G03, also L02, H01C) – human endogenous in SMALL CAPS
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Wikipedia content modification information:

  • This page was last modified on 12 December 2008, at 17:34.

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