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Butylscopolamine
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| Systematic (IUPAC) name | |
| [7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy- 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa- 9-azonitricyclo[3.3.1.0(2,4)]nonane |
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| Identifiers | |
| CAS number | |
| ATC code | A03 |
| PubChem | |
| Chemical data | |
| Formula | C21H30NO4+ |
| Mol. mass | 360.467 g/mol |
| Pharmacokinetic data | |
| Bioavailability | <1% |
| Protein binding | Low |
| Metabolism | ? |
| Half life | 5 hours |
| Excretion | Renal (50%) and fecal |
| Therapeutic considerations | |
| Pregnancy cat. |
B2(AU) |
| Legal status |
Pharmacy Only (S2)(AU) GSL(UK) |
| Routes | Oral, rectal, intravenous |
Butylscopolamine, also known as scopolamine butylbromide and hyoscine butylbromide is an anticholinergic agent[1] used as an abdominal-specific antispasmodic. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and acetaminophen, marketed under the name Buscopan Plus.
Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place.
Usage
Butylscopolamine is often prescribed at a low dosage, commonly 10mg three times a day, as a means of managing some of the symptoms of Irritable bowel syndrome.
References
- ^ Effects of -Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs Makoto Murakami, Yoshitaka Tomiyama, Kohichi Hayakawa, Masuo Akahane, Yukiyoshi Ajisawa, Young-Chol Park, Norio Ohnishi, Takahide Sugiyama and Takashi Kurita. Division of Discovery Research, Kissei Pharmaceutical Co., Ltd., Nagano (M.M., Y.T., K.H., M.A., Y.A.); and Department of Urology, Kinki University School of Medicine, Osaka, Japan (Y.-C.P., N.O., T.S., T.K.)
External links
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Wikipedia content modification information:
- This page was last modified on 3 July 2008, at 05:28.
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