C-fos induced growth factor

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C-fos induced growth factor (vascular endothelial growth factor D)
Identifiers
Symbols FIGF; VEGF-D; VEGFD
External IDs OMIM: 300091 MGI: 108037 HomoloGene: 3288
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2277 14205
Ensembl ENSG00000165197 ENSMUSG00000031380
Uniprot O43915 Q6P5N9
Refseq NM_004469 (mRNA)
NP_004460 (protein)		 XM_988606 (mRNA)
XP_993700 (protein)
Location Chr X: 15.27 - 15.31 Mb Chr X: 159.72 - 159.75 Mb
Pubmed search [1] [2]

C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D) is a vascular endothelial growth factor. FIGF is also its human gene.1

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.1

References

  1. ^ a b "Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Orlandini M, Marconcini L, Ferruzzi R, Oliviero S (1996). "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11675–80. PMID 8876195. 
  • Yamada Y, Nezu J, Shimane M, Hirata Y (1997). "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D.". Genomics 42 (3): 483–8. PMID 9205122. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Achen MG, Jeltsch M, Kukk E, et al. (1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53. PMID 9435229. 
  • Rocchigiani M, Lestingi M, Luddi A, et al. (1998). "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes.". Genomics 47 (2): 207–16. doi:10.1006/geno.1997.5079. PMID 9479493. 
  • Stacker SA, Stenvers K, Caesar C, et al. (1999). "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.". J. Biol. Chem. 274 (45): 32127–36. PMID 10542248. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakamura Y, Yasuoka H, Tsujimoto M, et al. (2003). "Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up.". Clin. Cancer Res. 9 (2): 716–21. PMID 12576440. 
  • Yokoyama Y, Charnock-Jones DS, Licence D, et al. (2003). "Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma.". Br. J. Cancer 88 (2): 237–44. doi:10.1038/sj.bjc.6600701. PMID 12610509. 
  • Rissanen TT, Markkanen JE, Gruchala M, et al. (2003). "VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.". Circ. Res. 92 (10): 1098–106. doi:10.1161/01.RES.0000073584.46059.E3. PMID 12714562. 
  • Funaki H, Nishimura G, Harada S, et al. (2003). "Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma.". Oncology 64 (4): 416–22. doi:10.1159/000070301. PMID 12759540. 
  • Orlandini M, Semboloni S, Oliviero S (2004). "Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability.". J. Biol. Chem. 278 (45): 44650–6. doi:10.1074/jbc.M304255200. PMID 12920128. 
  • McColl BK, Baldwin ME, Roufail S, et al. (2003). "Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.". J. Exp. Med. 198 (6): 863–8. doi:10.1084/jem.20030361. PMID 12963694. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Vlahakis NE, Young BA, Atakilit A, Sheppard D (2005). "The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.". J. Biol. Chem. 280 (6): 4544–52. doi:10.1074/jbc.M412816200. PMID 15590642. 
  • Kurahara H, Takao S, Maemura K, et al. (2005). "Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis.". Clin. Cancer Res. 10 (24): 8413–20. doi:10.1158/1078-0432.CCR-04-0379. PMID 15623620. 
  • Fink AM, Kaltenegger I, Schneider B, et al. (2005). "Serum level of VEGF-D in patients with primary lymphedema.". Lymphology 37 (4): 185–9. PMID 15693535. 
  • Kaushal V, Mukunyadzi P, Dennis RA, et al. (2005). "Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease.". Clin. Cancer Res. 11 (2 Pt 1): 584–93. PMID 15701844. 
  • Yasuoka H, Nakamura Y, Zuo H, et al. (2005). "VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma.". Mod. Pathol. 18 (8): 1127–33. doi:10.1038/modpathol.3800402. PMID 15803188. 
 This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.
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Growth factors
Fibroblast
FGF receptor ligands: 1 (acidic)/2 (basic)/5 · 3/4/6 · KGF (7/10/22) · 8/17/18 · 9/16/20

FGF homologous factors: 11 · 12 · 13 · 14

hormone-like: 19 · 21 · 23
EGF-like domain
TGFβ pathway
TGFβ (1, 2, 3)
Insulin-like
1 · 2
Platelet-derived
A · B · C · D
Vascular endothelial
A · B · C · D · PGF
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  • This page was last modified on 3 September 2008, at 12:33.

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