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C-src tyrosine kinase
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| PDB rendering based on 1byg. | ||||||||||||||
| Available structures: 1byg, 1csk, 1jeg, 1k9a | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | CSK; MGC117393 | |||||||||||||
| External IDs | OMIM: 124095 MGI: 88537 HomoloGene: 55818 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1445 | 12988 | ||||||||||||
| Ensembl | ENSG00000103653 | ENSMUSG00000032312 | ||||||||||||
| Uniprot | P41240 | Q3UVH2 | ||||||||||||
| Refseq | NM_004383 (mRNA) NP_004374 (protein) |
NM_007783 (mRNA) NP_031809 (protein) |
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| Location | Chr 15: 72.86 - 72.88 Mb | Chr 9: 57.42 - 57.44 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
C-src tyrosine kinase, also known as CSK, is a human protein and gene. It includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase, which acts as a negative regulatory site. It may also act on the LYN and FYN kinases.
See also
Further reading
- Mustelin T, Taskén K (2003). "Positive and negative regulation of T-cell activation through kinases and phosphatases.". Biochem. J. 371 (Pt 1): 15–27. doi:. PMID 12485116.
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Wikipedia content modification information:
- This page was last modified on 10 November 2008, at 09:43.
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