C3-convertase

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The classical and alternative complement pathways.

There are two forms of C3-convertase (EC 3.4.21.43).

  • The second consists of the C3bBb complex, which forms during the alternative complement pathway. It is formed when membrane bound C3b binds to factor B which is in turn cleaved by factor D into Ba and Bb. Bb remains bound to C3b while Ba is released into the surrounding medium.

Once formed, both C3-convertases will catalyze the proteolytic cleavage of C3 into C3a and C3b (hence the name "C3-convertase"). C3b can then act as an opsonizer or bind to activated bimolecular complex C4b2a to form a trimolecular complex, C5-convertase, which is a specific enzyme for C5.

A convertase (of either type) with an additional 3b (C4b2a3b or C3bBb3b) is known as "C5-convertase".

External links

v • d • e
Proteins: complement system (C, L, A)
Activators/enzymes
Early
C: C1Q/C1R/C1S - C4 (C4a) - C2
L: MASP1/MASP2 - MBL
Middle
CLA: C3 (C3a, C3b/iC3b) - C5 (C5a)

A: Factor B - Factor D - Factor P/Properdin

CLA: C3-convertase - C5-convertase
Late
CLA: MAC (C6, C7, C8, C9)
Inhibitors
Complement receptors
v • d • e
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes
Coagulation
Complement system
Factor B - Factor D - Factor I - MASP (MASP1, MASP2) - C3-convertase
Other immune system
Venombin
Other
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