C4b-binding protein

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complement component 4 binding protein, alpha
Identifiers
Symbol C4BPA
Alt. Symbols C4BP
Entrez 722
HUGO 1325
OMIM 120830
RefSeq NM_000715
UniProt P04003
Other data
Locus Chr. 1 q32
complement component 4 binding protein, beta
Identifiers
Symbol C4BPB
Alt. Symbols C4BP
Entrez 725
HUGO 1328
OMIM 120831
RefSeq NM_000716
UniProt P20851
Other data
Locus Chr. 1 q32

C4BP is a protein involved in the complement system. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains.

Functions

It inhibits the action of C4, more specifically the classical pathway. It splits C4 convertase and is a cofactor for factor I which cleaves C4b.

C4BP binds necrotic cells and DNA, to clean up after swelling.

It also binds CD40 on B cells which potentiaties proliferation and costimulation.

External links

 This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteins: complement system (C, L, A)
Activators/enzymes
Early
C: C1Q/C1R/C1S - C4 (C4a) - C2
L: MASP1/MASP2 - MBL
Middle
Late
CLA: MAC (C6, C7, C8, C9)
Inhibitors
Complement receptors

Wikipedia content modification information:

  • This page was last modified on 22 October 2008, at 02:24.

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