CACNB1

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Calcium channel, voltage-dependent, beta 1 subunit
PDB rendering based on 1t0h.
Available structures: 1t0h, 1t0j
Identifiers
Symbols CACNB1; CAB1; CACNLB1; CCHLB1; MGC41896
External IDs OMIM: 114207 MGI: 102522 HomoloGene: 20186
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 782 12295
Ensembl ENSG00000067191 ENSMUSG00000020882
Uniprot Q02641 Q6DD95
Refseq NM_000723 (mRNA)
NP_000714 (protein)		 XM_978622 (mRNA)
XP_983716 (protein)
Location Chr 17: 34.58 - 34.61 Mb Chr 11: 97.82 - 97.84 Mb
Pubmed search [1] [2]

Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene.1

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.1

Contents

See also

References

  1. ^ a b "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit".

Further reading

  • Williams ME, Feldman DH, McCue AF, et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.". Neuron 8 (1): 71–84. doi:10.1016/0896-6273(92)90109-Q. PMID 1309651. 
  • Perez-Reyes E, Castellano A, Kim HS, et al. (1992). "Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.". J. Biol. Chem. 267 (3): 1792–7. PMID 1370480. 
  • Powers PA, Liu S, Hogan K, Gregg RG (1992). "Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.". J. Biol. Chem. 267 (32): 22967–72. PMID 1385409. 
  • Pragnell M, Sakamoto J, Jay SD, Campbell KP (1991). "Cloning and tissue-specific expression of the brain calcium channel beta-subunit.". FEBS Lett. 291 (2): 253–8. doi:10.1016/0014-5793(91)81296-K. PMID 1657644. 
  • Collin T, Wang JJ, Nargeot J, Schwartz A (1993). "Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart.". Circ. Res. 72 (6): 1337–44. PMID 7916667. 
  • Gregg RG, Powers PA, Hogan K (1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping.". Genomics 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767. 
  • Iles DE, Segers B, Sengers RC, et al. (1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility.". Hum. Mol. Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940. 
  • Fukuda K, Kaneko S, Yada N, et al. (1997). "Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.". Neurosci. Lett. 217 (1): 13–6. PMID 8905728. 
  • Gregg RG, Messing A, Strube C, et al. (1997). "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13961–6. doi:10.1073/pnas.93.24.13961. PMID 8943043. 
  • Brice NL, Dolphin AC (1999). "Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.". J. Physiol. (Lond.) 515 ( Pt 3): 685–94. doi:10.1111/j.1469-7793.1999.685ab.x. PMID 10066897. 
  • Lie AA, Blümcke I, Volsen SG, et al. (1999). "Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy.". Neuroscience 93 (2): 449–56. doi:10.1016/S0306-4522(99)00162-1. PMID 10465427. 
  • Hogan K, Greg RG, Powers PA (2000). "Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels.". Neurosci. Lett. 277 (2): 111–4. doi:10.1016/S0304-3940(99)00851-4. PMID 10624822. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Finlin BS, Crump SM, Satin J, Andres DA (2004). "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 14469–74. doi:10.1073/pnas.2437756100. PMID 14623965. 
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. 
  • Foell JD, Balijepalli RC, Delisle BP, et al. (2004). "Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization.". Physiol. Genomics 17 (2): 183–200. doi:10.1152/physiolgenomics.00207.2003. PMID 14762176. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

External links

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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm (1, 2, 3, 4)  • Two-pore channel (1, 2)
Ligand-gated
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) • (2.1, 2.2) • (3.1, 3.2, 3.3, 3.4) • (4.1, 4.2, 4.3) • (5.1) • (6.1, 6.2, 6.3, 6.4)
Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) • (8.1, 8.2) • (9.1, 9.2, 9.3) • (10.1, 10.2) • (11.1/hERG, 11.2, 11.3) • (12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • minK/ISK-like • MiRP (1, 2, 3) • Shaker gene
BK channel (α1, β1, β2, β3, β4) • SK channel (SK1, SK2, SK3, SK4) • KCa (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
ANO1 • Bestrophin (1, 2)  • CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
Cyclic nucleotide-gated (FC)
α (1, 2, 3, 4) • β (1, 2, 3) • HCN (1, 2, 3, 4)
Porin
Other/general

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  • This page was last modified on 14 October 2008, at 05:40.

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