CARM1

This MedLibrary.org supplementary page on CARM1 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

coactivator-associated arginine methyltransferase 1
Identifiers
Symbol CARM1
Entrez 10498
HUGO 23393
OMIM 603934
RefSeq XM_032719
UniProt Q86X55
Other data
EC number 2.1.1.125
Locus Chr. 19 p13.2
coactivator associated arginine methyltransferase 1-like
Identifiers
Symbol CARM1L
Entrez 256280
HUGO 23392
RefSeq XM_171224
UniProt Q5SZY8
Other data
Locus Chr. 9 p24.2

CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.1 CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.2 This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.34

See also

External links

References

  1. ^ Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase". Science 284 (5423): 2174–7. doi:10.1126/science.284.5423.2174. PMID 10381882. 
  2. ^ Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007). "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature 445 (7124): 214–8. doi:10.1038/nature05458. PMID 17215844. 
  3. ^ Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L (2004). "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status". Cancer 101 (1): 83–9. doi:10.1002/cncr.20327. PMID 15221992. 
  4. ^ Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE (2006). "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743. 



 This biology article is a stub. You can help Wikipedia by expanding it.


v • d • e
Transcription coregulators
Coactivators
ARA (54, 55, 70) • CARM1 • CBP • CRTC (1, 2, 3) • DRIP/TRAP • MN1 • PCAF • PNRC (1, 2) • PPARGC (1A, 1B) • TGFB1I1
NCOA1 (SRC-1) • NCOA2 (GRIP1/SRC-2/TIF2) • NCOA3 (AIB/SRC-3/TRAM-1) • NCOA4 (ARA70) • NCOA5 (CIA) • NCOA6 (RAP250) • NCOA7 (ERAP140)
Corepressors
Hairless homolog • NRIP1 (RIP140) • PELP-1 • RCOR1 • Rb • SIN3A • SIN3B • Tripartite motif family TRIM (24, 28, 33)
NCOR1 • NCOR2 (SMRT)
ATP-dependent remodeling factors

Wikipedia content modification information:

  • This page was last modified on 27 August 2008, at 20:00.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "CARM1".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.