CBX1

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Chromobox homolog 1 (HP1 beta homolog Drosophila )
PDB rendering based on 1ap0.
Available structures: 1ap0, 1dz1, 1guw, 1s4z, 2fmm
Identifiers
Symbols CBX1; CBX; HP1-BETA; HP1Hs-beta; M31; MOD1
External IDs OMIM: 604511 MGI: 105369 HomoloGene: 38228
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10951 12412
Ensembl ENSG00000108468 ENSMUSG00000018666
Uniprot P83916 Q7TPM0
Refseq NM_006807 (mRNA)
NP_006798 (protein)		 XM_990275 (mRNA)
XP_995369 (protein)
Location Chr 17: 43.5 - 43.53 Mb Chr 11: 96.61 - 96.62 Mb
Pubmed search [1] [2]

Chromobox homolog 1 (HP1 beta homolog Drosophila ), also known as CBX1, is a human gene.1

Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]1

Contents

See also

References

  1. ^ a b "Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )".

Further reading

  • Furuta K, Chan EK, Kiyosawa K, et al. (1997). "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis.". Chromosoma 106 (1): 11–9. PMID 9169582. 
  • Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells.". Blood 91 (4): 1216–24. PMID 9454751. 
  • Aagaard L, Laible G, Selenko P, et al. (1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.". EMBO J. 18 (7): 1923–38. doi:10.1093/emboj/18.7.1923. PMID 10202156. 
  • Minc E, Allory Y, Worman HJ, et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.". Chromosoma 108 (4): 220–34. PMID 10460410. 
  • Murzina N, Verreault A, Laue E, Stillman B (1999). "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins.". Mol. Cell 4 (4): 529–40. PMID 10549285. 
  • Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMID 10562550. 
  • Brasher SV, Smith BO, Fogh RH, et al. (2000). "The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer.". EMBO J. 19 (7): 1587–97. doi:10.1093/emboj/19.7.1587. PMID 10747027. 
  • Zhao T, Heyduk T, Allis CD, Eissenberg JC (2000). "Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.". J. Biol. Chem. 275 (36): 28332–8. doi:10.1074/jbc.M003493200. PMID 10882726. 
  • Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053. 
  • Bannister AJ, Zegerman P, Partridge JF, et al. (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.". Nature 410 (6824): 120–4. doi:10.1038/35065138. PMID 11242054. 
  • Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.". Mol. Cell 7 (4): 729–39. PMID 11336697. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298. 
  • Scholzen T, Endl E, Wohlenberg C, et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure.". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364. 
  • Nielsen PR, Nietlispach D, Mott HR, et al. (2002). "Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.". Nature 416 (6876): 103–7. doi:10.1038/nature722. PMID 11882902. 
  • Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. doi:10.1073/pnas.092025499. PMID 11959914. 
  • Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1.". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505. 
  • Bhattacharya N, Wang Z, Davitt C, et al. (2003). "Pim-1 associates with protein complexes necessary for mitosis.". Chromosoma 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. PMID 12111331. 
  • Lin CY, Li CC, Huang PH, Lee FJ (2003). "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.". J. Cell. Sci. 115 (Pt 23): 4433–45. PMID 12414990. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Festenstein R, Pagakis SN, Hiragami K, et al. (2003). "Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells.". Science 299 (5607): 719–21. doi:10.1126/science.1078694. PMID 12560554. 

External links


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