CD20

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Membrane-spanning 4-domains, subfamily A, member 1
Identifiers
Symbols MS4A1; B1; Bp35; CD20; LEU-16; MGC3969; MS4A2; S7
External IDs OMIM: 112210 MGI: 88321 HomoloGene: 7259
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 931 12482
Ensembl ENSG00000156738 ENSMUSG00000024673
Uniprot P11836 Q542S5
Refseq NM_021950 (mRNA)
NP_068769 (protein)		 NM_007641 (mRNA)
NP_031667 (protein)
Location Chr 11: 59.98 - 59.99 Mb Chr 19: 11.32 - 11.33 Mb
Pubmed search [2] [3]

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.

Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene.[1]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.[1]

Contents

Function

The protein has no known natural ligand[2] and its function is unclear. It is suspected that it acts as a calcium channel in the cell membrane. It is also found on B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia. It is also found on skin/melanoma cancer stem cells.[3]

Clinical significance

It is the target of the monoclonal antibodies rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Additional antibody therapeutics under development (phase II or III clinical trials) include AME-133v (Applied Molecular Evolution), Ocrelizumab (Roche), Ofatumumab (Genmab), TRU-015 (Trubion) and IMMU-106 (Immunomedics).[4]

FMC7 appears to be a conformational variant.[5]

References

  1. ^ a b "Entrez Gene: MS4A1 membrane-spanning 4-domains, subfamily A, member 1".
  2. ^ The biology of CD20 and its potential as a target for mAb therapy.[1]
  3. ^ Fang D, Nguyen TK, Leishear K, et al (2005). "A tumorigenic subpopulation with stem cell properties in melanomas". Cancer Res. 65 (20): 9328–37. doi:10.1158/0008-5472.CAN-05-1343. PMID 16230395. 
  4. ^ Note: information included in this article only found in table present in print version of article. K. John Morrow Jr (2008-06-15). "Methods for Maximizing Antibody Yields", Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., p. 36. Retrieved on 2008-07-06. 
  5. ^ Polyak MJ, Ayer LM, Szczepek AJ, Deans JP (2003). "A cholesterol-dependent CD20 epitope detected by the FMC7 antibody". Leukemia 17 (7): 1384–9. doi:10.1038/sj.leu.2402978. PMID 12835728. 

Further reading

  • Macardle PJ, Nicholson IC (2003). "CD20.". J. Biol. Regul. Homeost. Agents 16 (2): 136–8. PMID 12144126. 
  • Tamayose K, Sato N, Ando J, et al. (2002). "CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature.". Am. J. Hematol. 71 (4): 331–5. doi:10.1002/ajh.10224. PMID 12447967. 
  • Küster H, Zhang L, Brini AT, et al. (1992). "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.". J. Biol. Chem. 267 (18): 12782–7. PMID 1535625. 
  • Tedder TF, Streuli M, Schlossman SF, Saito H (1988). "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 85 (1): 208–12. PMID 2448768. 
  • Einfeld DA, Brown JP, Valentine MA, et al. (1988). "Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains.". EMBO J. 7 (3): 711–7. PMID 2456210. 
  • Tedder TF, Disteche CM, Louie E, et al. (1989). "The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site.". J. Immunol. 142 (7): 2555–9. PMID 2466898. 
  • Tedder TF, Klejman G, Schlossman SF, Saito H (1989). "Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).". J. Immunol. 142 (7): 2560–8. PMID 2466899. 
  • Loken MR, Shah VO, Dattilio KL, Civin CI (1987). "Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development.". Blood 70 (5): 1316–24. PMID 3117132. 
  • Stamenkovic I, Seed B (1988). "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.". J. Exp. Med. 167 (6): 1975–80. PMID 3260267. 
  • Bofill M, Janossy G, Janossa M, et al. (1985). "Human B cell development. II. Subpopulations in the human fetus.". J. Immunol. 134 (3): 1531–8. PMID 3871452. 
  • Deans JP, Kalt L, Ledbetter JA, et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632–8. PMID 7545683. 
  • Valentine MA, Licciardi KA, Clark EA, et al. (1993). "Insulin regulates serine/threonine phosphorylation in activated human B lymphocytes.". J. Immunol. 150 (1): 96–105. PMID 7678037. 
  • Bubien JK, Zhou LJ, Bell PD, et al. (1993). "Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.". J. Cell Biol. 121 (5): 1121–32. PMID 7684739. 
  • Shirakawa T, Li A, Dubowitz M, et al. (1994). "Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.". Nat. Genet. 7 (2): 125–9. doi:10.1038/ng0694-125. PMID 7920628. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Szepetowski P, Perucca-Lostanlen D, Gaudray P (1993). "Mapping genes according to their amplification status in tumor cells: contribution to the map of 11q13.". Genomics 16 (3): 745–50. PMID 8325649. 
  • Algino KM, Thomason RW, King DE, et al. (1996). "CD20 (pan-B cell antigen) expression on bone marrow-derived T cells.". Am. J. Clin. Pathol. 106 (1): 78–81. PMID 8701937. 
  • Szöllósi J, Horejsí V, Bene L, et al. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.". J. Immunol. 157 (7): 2939–46. PMID 8816400. 
  • Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein.". J. Biol. Chem. 272 (23): 14733–9. PMID 9169438. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 

External links


v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
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