CDC42

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Cell division cycle 42 (GTP binding protein, 25kDa)
PDB rendering based on 1a4r.
Available structures: 1a4r, 1aje, 1am4, 1an0, 1cee, 1cf4, 1doa, 1e0a, 1ees, 1grn, 1gzs, 1ki1, 1kz7, 1kzg, 1nf3, 2ase, 2dfk, 2ngr, 2odb
Identifiers
Symbols CDC42; CDC42Hs; G25K
External IDs OMIM: 116952 MGI: 106211 HomoloGene: 1357
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 998 12540
Ensembl ENSG00000070831 ENSMUSG00000006699
Uniprot P60953 Q99JI7
Refseq NM_001039802 (mRNA)
NP_001034891 (protein)		 NM_009861 (mRNA)
NP_033991 (protein)
Location Chr 1: 22.24 - 22.29 Mb Chr 4: 136.59 - 136.63 Mb
Pubmed search [1] [2]

CDC42 is a protein involved in regulation of the cell cycle.

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.[1]

References

  1. ^ "Entrez Gene: CDC42 cell division cycle 42 (GTP binding protein, 25kDa)".

Further reading

  • Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition.". Trends Neurosci. 25 (4): 191–9. PMID 11998687. 

External links

 This hydrolase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap
3.6.5.3: Elongation factor
3.6.5.5-6: Other
Dynamin (is a GTPase, is not a G protein) - Tubulin
v • d • e
Cell cycle proteins
Cyclin
D - E - A - B
Cyclin-dependent kinase
2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase
Cyclin-dependent kinase inhibitor protein
Other
v • d • e
Rho family of GTPases
Cdc42 (Cdc42, TC10, TCL, Wrch1, Chp) • Rac (Rac1, Rac2, Rac3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1 - 2 - 3) • RhoD (Rif)


Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 05:12.

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