CGS-20625

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CGS-20625
Systematic (IUPAC) name
5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
Identifiers
CAS number 111205-55-1
ATC code  ?
PubChem 163844
Chemical data
Formula C18H19N3O2 
Mol. mass 309.36236 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 41%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes oral

CGS-20625 is an anxiolytic drug used in scientific research. It has similar effects to, and binds to the same target as benzodiazepine drugs,1 but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.23

CGS-20625 produces anxiolytic and anticonvulsant effects, but with no sedative effects even at high doses, and no significant muscle relaxant effects.4 It is orally active in humans, but with relatively low bioavailability.5


Diazepam This article about an anxiolytic is a stub. You can help Wikipedia by expanding it.


References

  1. ^ Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S (Feb 2006). "Pharmacological properties of GABAA receptors containing gamma1 subunits". Mol Pharmacol. 69 (2): 640–9. doi:10.1124/mol.105.017236. PMID 16272224. 
  2. ^ Bennett DA (1987). "Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions". Physiol. Behav. 41 (3): 241–5. doi:10.1016/0031-9384(87)90360-X. PMID 2893398. http://linkinghub.elsevier.com/retrieve/pii/0031-9384(87)90360-X. 
  3. ^ Brunner LA, Luders RC (Aug 1991). "Determination of a potential anxiolytic drug (CGS 20625) in human plasma by high-performance liquid chromatography". J Chromatogr. 568 (2): 487–93. doi:10.1016/0378-4347(91)80188-I. PMID 1686029. 
  4. ^ Williams M, Bennett DA, Loo PS, et al (Jan 1989). "CGS 20625, a novel pyrazolopyridine anxiolytic". J Pharmacol Exp Ther. 248 (1): 89–96. PMID 2563294. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2563294. 
  5. ^ Hirschberg Y, Oberle RL, Ortiz M, Lau H, Markowska M (Feb 1995). "Oral absorption of CGS-20625, an insoluble drug, in dogs and man". J Pharmacokinet Biopharm 23 (1): 11–23. doi:10.1007/BF02353783. PMID 8576841. 


v • d • e
Psycholeptics: anxiolytics (tranquilisers) (N05B)
GABAA receptor
Adipiplon • Alpidem • CGS-9896 • CGS-20625 • DOV-51892 • ELB-139 • Etifoxine • L-838,417 • MK-0343 • NS-2664 • NS-2710 • Ocinaplon • Pagoclone • Panadiplon • Pipequaline • RWJ-51204 • SB-205,384 • TP-003 • TP-13 • TPA-023 • Tracazolate • Y-23684
Serotonin agonist
Histamine antagonist
CRF antagonists
CRF-1 antagonists
Other/ungrouped
Dibenzobicyclooctadiene
Other

Wikipedia content modification information:

  • This page was last modified on 25 November 2008, at 22:43.

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