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CGS-9896
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| Systematic (IUPAC) name | |
| 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C16H10ClN3O |
| Mol. mass | 295.7231 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.1
CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.23 It also increases appetite,4 and reduces the development of gastrointestinal ulcers following chronic stress.5
 This article about an anxiolytic is a stub. You can help Wikipedia by expanding it. |
References
- ^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:. PMID 2854261. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90342-5.
- ^ Bernasconi R, Marescaux C, Vergnes M, et al (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:. PMID 3343593.
- ^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch Toxicol. 64 (5): 412–3. doi:. PMID 2206111.
- ^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2-3): 499–503. doi:. PMID 7667375. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)00020-W.
- ^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:. PMID 2109664.
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Wikipedia content modification information:
- This page was last modified on 25 November 2008, at 22:48.
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