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| CGS-21680 | |
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| IUPAC name | 3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid |
| Other names | CGS 21680 |
| Identifiers | |
| CAS number | 120225-54-9 |
| PubChem | |
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| Properties | |
| Molecular formula | C23H29N7O6 |
| Molar mass | 499.52 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.
The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.
It is currently manufactured by Tocris with the exclusive permission of Novartis Pharma AG, U.S. Patent 4,968,697.
See also
References
- Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol 100 (1): 91–97. doi:. PMID 16141383.
- Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater 15 (2-3): 225–228. doi:.
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- This page was last modified on 20 December 2008, at 14:22.
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