CHRNA10

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cholinergic receptor, nicotinic, alpha 10
Identifiers
Symbol CHRNA10
Entrez 57053
HUGO 13800
OMIM 606372
RefSeq NM_020402
UniProt Q9GZZ6
Other data
Locus Chr. 11 p15.5

Cholinergic receptor, nicotinic, alpha 10, also known as CHRNA10, is a human gene.1 The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.2 Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.3

References

  1. ^ Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119. 
  2. ^ Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMID 18077337. 
  3. ^ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMID 17101979. 

External links

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  • This page was last modified on 9 July 2008, at 09:42.

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