CHRNA6

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Cholinergic receptor, nicotinic, alpha 6
Identifiers
Symbols CHRNA6; CHNRA6
External IDs OMIM: 606888 MGI: 106213 HomoloGene: 20888
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8973 11440
Ensembl ENSG00000147434 ENSMUSG00000031491
Uniprot Q15825 Q3UEY4
Refseq NM_004198 (mRNA)
NP_004189 (protein)		 NM_021369 (mRNA)
NP_067344 (protein)
Location Chr 8: 42.73 - 42.74 Mb Chr 8: 28.87 - 28.88 Mb
Pubmed search [1] [2]

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene,1 which codes for the α6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain,2 and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.345 Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.67


Contents

See also

References

  1. ^ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6".
  2. ^ Meyer EL, Yoshikami D, McIntosh JM. The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices. Journal of Neurochemistry. 2008 Jun;105(5):1761-9. PMID 18248619
  3. ^ Calabresi P, Massimiliano DF. ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing Nicotinic Receptors? Neuron. 2008 Oct; 60(1):4-7.
  4. ^ Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, McIntosh JM, Bencherif M, Marks MJ, Lester HA. In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6 Nicotinic Acetylcholine Receptors. Neuron. 2008 Oct; 60(1):123-136.
  5. ^ Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ. Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66. PMID 18033235
  6. ^ Quik M, McIntosh JM. Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy. Journal of Pharmacology and Experimental Therapeutics. 2006 Feb;316(2):481-9. PMID 16210393
  7. ^ Bordia T, Grady SR, McIntosh JM, Quik M. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Molecular Pharmacology. 2007 Jul;72(1):52-61. PMID 17409284

Further reading

  • Zeiger JS, Haberstick BC, Schlaepfer I, et al. (2008). "The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.". Hum. Mol. Genet. 17 (5): 724-34. doi:10.1093/hmg/ddm344. PMID 18055561. 
  • Shi J, Hattori E, Zou H, et al. (2007). "No evidence for association between 19 cholinergic genes and bipolar disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (6): 715-23. doi:10.1002/ajmg.b.30417. PMID 17373692. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Keiger CJ, Case LD, Kendal-Reed M, et al. (2003). "Nicotinic cholinergic receptor expression in the human nasal mucosa.". Ann. Otol. Rhinol. Laryngol. 112 (1): 77-84. PMID 12537063. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ebihara M, Ohba H, Ohno SI, Yoshikawa T (2003). "Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression.". Gene 298 (1): 101-8. PMID 12406580. 
  • Graham A, Court JA, Martin-Ruiz CM, et al. (2002). "Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum.". Neuroscience 113 (3): 493-507. PMID 12150770. 
  • Le Novère N, Zoli M, Changeux JP (1997). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain.". Eur. J. Neurosci. 8 (11): 2428-39. PMID 8950106. 
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217-28. doi:10.1007/BF02736842. PMID 8906617. 

External links

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v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) • GABA C (ρ1, ρ2, ρ3)
α1 • α2 • α3 • α4 • β
monomers: α1 • α2 • α3 • α4 • α5 • α6 • α7 • α9 • α10 • β1 • β2 • β3 • β4 • δ • ε
pentamers: (α4)2(β2)3 • (α7)5 • (α1)2(β4)3 - Ganglion type • (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
AMPA (1, 2, 3, 4) • Kainate (1, 2, 3, 4, 5)  • NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels

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