CHRNA9

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Cholinergic receptor, nicotinic, alpha 9
Identifiers
Symbols CHRNA9; HSA243342; MGC142109; MGC142135; NACHRA9
External IDs OMIM: 605116 MGI: 1202403 HomoloGene: 9729
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55584 231252
Ensembl ENSG00000174343 ENSMUSG00000029205
Uniprot Q9UGM1 n/a
Refseq NM_017581 (mRNA)
NP_060051 (protein)		 XM_132045 (mRNA)
XP_132045 (protein)
Location Chr 4: 40.03 - 40.05 Mb Chr 5: 66.25 - 66.26 Mb
Pubmed search [1] [2]

Cholinergic receptor, nicotinic, alpha 9, also known as CHRNA9, is a human gene.1

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.1

Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.2

Contents

See also

References

  1. ^ a b "Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9".
  2. ^ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMID 17101979. 

Further reading

  • Nguyen VT, Ndoye A, Grando SA (2000). "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity.". Am. J. Pathol. 157 (4): 1377–91. PMID 11021840. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Sgard F, Charpantier E, Bertrand S, et al. (2002). "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit.". Mol. Pharmacol. 61 (1): 150–9. PMID 11752216. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lustig LR, Peng H (2003). "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene.". Cytogenet. Genome Res. 98 (2-3): 154–9. doi:10.1159/000069804. PMID 12697997. 
  • Valor LM, Castillo M, Ortiz JA, Criado M (2003). "Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene.". J. Biol. Chem. 278 (39): 37249–55. doi:10.1074/jbc.M307043200. PMID 12860975. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Peng H, Ferris RL, Matthews T, et al. (2004). "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes.". Life Sci. 76 (3): 263–80. doi:10.1016/j.lfs.2004.05.031. PMID 15531379. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Chernyavsky AI, Arredondo J, Vetter DE, Grando SA (2007). "Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization.". Exp. Cell Res. 313 (16): 3542–55. doi:10.1016/j.yexcr.2007.07.011. PMID 17706194. 

External links

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v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) • GABA C (ρ1, ρ2, ρ3)
α1 • α2 • α3 • α4 • β
monomers: α1 • α2 • α3 • α4 • α5 • α6 • α7 • α9 • α10 • β1 • β2 • β3 • β4 • δ • ε
pentamers: (α4)2(β2)3 • (α7)5 • (α1)2(β4)3 - Ganglion type • (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
AMPA (1, 2, 3, 4) • Kainate (1, 2, 3, 4, 5)  • NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels

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