CLDN3

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Claudin 3
Identifiers
Symbols CLDN3; C7orf1; CPE-R2; CPETR2; HRVP1; RVP1
External IDs OMIM: 602910 MGI: 1329044 HomoloGene: 1001
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1365 12739
Ensembl ENSG00000165215 ENSMUSG00000070473
Uniprot O15551 Q3TMQ3
Refseq NM_001306 (mRNA)
NP_001297 (protein)		 NM_009902 (mRNA)
NP_034032 (protein)
Location Chr 7: 72.82 - 72.82 Mb Chr 5: 135.27 - 135.27 Mb
Pubmed search [1] [2]

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.1 It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.1

References

  1. ^ a b "Entrez Gene: CLDN3 claudin 3".

Further reading

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. PMID 10690502. 
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. PMID 11247307. 
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. 
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. PMID 12231346. 
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. PMID 12475568. 
  • Katahira J, Sugiyama H, Inoue N, et al. (1997). "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.". J. Biol. Chem. 272 (42): 26652–8. PMID 9334247. 
  • Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein.". Genomics 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748. 
  • Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. PMID 9892664. 
  • Furuse M, Sasaki H, Tsukita S (1999). "Manner of interaction of heterogeneous claudin species within and between tight junction strands.". J. Cell Biol. 147 (4): 891–903. PMID 10562289. 
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. PMID 10601346. 
  • Miyamori H, Takino T, Kobayashi Y, et al. (2001). "Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases.". J. Biol. Chem. 276 (30): 28204–11. doi:10.1074/jbc.M103083200. PMID 11382769. 
  • Long H, Crean CD, Lee WH, et al. (2001). "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium.". Cancer Res. 61 (21): 7878–81. PMID 11691807. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.". Int. J. Mol. Med. 11 (6): 683–9. PMID 12736707. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
 This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.

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  • This page was last modified on 9 November 2008, at 07:20.

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