This MedLibrary.org supplementary page on CYP2E1 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
|
Cytochrome P450, family 2, subfamily E, polypeptide 1
|
||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | CYP2E1; CPE1; CYP2E; P450-J; P450C2E | |||||||||||||
| External IDs | OMIM: 124040 MGI: 88607 HomoloGene: 68089 | |||||||||||||
|
||||||||||||||
| RNA expression pattern | ||||||||||||||
|
|
||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1571 | 13106 | ||||||||||||
| Ensembl | ENSG00000130649 | ENSMUSG00000025479 | ||||||||||||
| Uniprot | P05181 | Q05421 | ||||||||||||
| Refseq | NM_000773 (mRNA) NP_000764 (protein) |
NM_021282 (mRNA) NP_067257 (protein) |
||||||||||||
| Location | Chr 10: 135.19 - 135.22 Mb | Chr 7: 140.62 - 140.63 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.
Contents |
CYP2E1 Ligands
| Substrates | Inhibitors | Inducers |
|---|---|---|
| Often mentioned: [2]
Other:
|
Strong: [3]
unspecified: |
|
Regulation of CYP2E1
Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transcriptional induction at high levels of ethanol[4]
See also
References
- ^ Where classes of agents are listed, there may be exceptions within the class
- ^ Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
- ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
- ^ Charles S. Lieber. 1999. Microsomal Ethanol-Oxidizing System (MEOS) The First 30 Years (1968-1998)-A Review. Alcoholism: Clinical and Experimental Research 23(6):991-1007
Further reading
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. PMID 9890157.
- Kessova I, Cederbaum AI (2003). "CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury". Curr. Mol. Med. 3 (6): 509–18. doi:. PMID 14527082.
|
||||||||||||||||||||||||||
|
||||||||||||||||||||
Wikipedia content modification information:
- This page was last modified on 8 July 2008, at 00:52.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "CYP2E1".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.