This MedLibrary.org supplementary page on Calcium-induced calcium release is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
Calcium-induced calcium release (CICR) is a mechanism of calcium release from muscle sarcoplasmic reticulum that was proposed in the 1970s[1]. Originally proposed for skeletal muscle, subsequent research has revealed that it is actually the predominant mechanism in cardiac muscle.
Contents |
CICR in Excitation-Contraction (EC) Coupling
The mechanism that couples excitation - an action potential in the plasma membrane of the muscle cell - and contraction of heart muscle is an increase in the cell's cystolic calcium concentration. This calcium combines with the regulator protein troponin, initiating cross-bridge formation between actin and myosin.
The Paradox of Regenerative Release
Termination of CICR
References
- ^ Endo M. (1977). "Calcium release from the sarcoplasmic reticulum.". Physiol Rev 57 (1): 71–108. PMID 13441.
 |
This biology article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 31 May 2008, at 20:53.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Calcium-induced calcium release".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.