Captopril suppression test

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Aldosterone (chemical structure) is measured in the CST.
Aldosterone (chemical structure) is measured in the CST.

In medicine, the captopril suppression test, also CST, is a non-invasive test used to help diagnose primary aldosteronism (Conn syndrome). It should not be confused with the captopril challenge test.

In the captopril suppression test the plasma aldosterone is measured.[1] In normal individuals aldosterone is suppressed by captopril, via the renin-angiotensin-aldosterone system.

Relation to captopril challenge test

The CST should not be confused with the captopril challenge test,[2][1] a test used to diagnose renal artery stenosis.

The challenge test looks for a problem with the renal artery (stenosis). The suppression test looks for a problem related to the adrenal gland (over production of a mineralocorticoids).

References

  1. ^ a b Agharazii M, Douville P, Grose JH, Lebel M (June 2001). "Captopril suppression versus salt loading in confirming primary aldosteronism". Hypertension 37 (6): 1440–3. PMID 11408392. 
  2. ^ Racine MC, Douville P, Lebel M (June 2002). "Functional tests for primary aldosteronism: value of captopril suppression". Curr. Hypertens. Rep. 4 (3): 245–9. PMID 12003708. 
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