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Cathepsin B
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| Available structures: 1csb, 1gmy, 1huc, 1pbh, 1sp4, 2ipp, 2pbh, 3pbh | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | CTSB; APPS; CPSB | |||||||||||||
| External IDs | OMIM: 116810 MGI: 88561 HomoloGene: 37550 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1508 | 13030 | ||||||||||||
| Ensembl | ENSG00000164733 | ENSMUSG00000021939 | ||||||||||||
| Uniprot | P07858 | Q3TC17 | ||||||||||||
| Refseq | NM_001908 (mRNA) NP_001899 (protein) |
NM_007798 (mRNA) NP_031824 (protein) |
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| Location | Chr 8: 11.74 - 11.76 Mb | Chr 14: 62.08 - 62.1 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cathepsin B, also known as CTSB, is a human gene.
Contents |
Function
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of β-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade β-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.[1][2]. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.[3]
See also
References
- ^ Mueller-Steiner S, Zhou Y, Arai H, Roberson E, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (2006). "Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease". Neuron 51 (6): 703–14. doi:. PMID 16982417.
- ^ "Enzyme shreds Alzheimer's protein" (2006-09-21). Retrieved on 2007-11-07.
- ^ "Entrez Gene: CTSB cathepsin B".
Further reading
- Yan S, Sloane BF (2004). "Molecular regulation of human cathepsin B: implication in pathologies.". Biol. Chem. 384 (6): 845–54. PMID 12887051.
External links
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Wikipedia content modification information:
- This page was last modified on 6 August 2008, at 12:51.
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