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Cefuroxime
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| Systematic (IUPAC) name | |
| 4-(carbamoyloxymethyl)-8- [2-(2-furyl)-2-methoxyimino-acetyl]amino -7-oxo-
2-thia-6-azabicyclo[4.2.0]oct -4-ene-5-carboxylic acid |
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| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H16N4O8S |
| Mol. mass | 424.386 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 37% on empty stomach, up to 52% if taken after food |
| Metabolism | axetil moiety is metabolized to acetaldehyde and acetic acid |
| Half life | 80 minutes |
| Excretion | Urine 66-100% Unchanged |
| Therapeutic considerations | |
| Pregnancy cat. |
Not known to be harmful (BNF) |
| Legal status |
Prescription Only Medicine(UK/USA) |
| Routes | oral, intramuscular, intravenous |
Cefuroxime is a second-generation cephalosporin antibiotic that has been widely available in the USA as Ceftin since 1977. Glaxo Smith Kline sells the antibiotic in Australia (and other countries, such as Cyprus, Israel and Poland) under the name Zinnat[1], with the Australian pharmaceutical code of R 47621. In the Philippines, a brand name Shincef has been used. In Poland it is also produced by the Polish firm Bioton S.A. under the name Biofuroksym.[2] In Cyprus, the box of the 500mg tablets is white with a wide red stripe on the left and contains two blister cards of seven. The tablets are long white and are marked "GX EG2". The Cypriot license for this is 16847. The 250mg tablets come in a similar box with a blue stripe.
According to the package insert supplied with Zinnat, cefuroxime is manufactured as tablets, as a powder to be mixed with water and ingested, as well as a sodium salt, the latter designed for medical injection. The Biofuroksym form of cefuroxime is designed for injection by a person with medical training.
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Brands
- Axet (500mg tablet) (Xeno Pharmaceuticals), Philippines
- Ecocef (750mg IV) (Xeno Pharmaceuticals), Philippines
- Ceftum (GlaxoSmithKline), India
- Kefstar (Wockhardt)
- Cefteja (Quadra)
- Altacef (Glenmark)
- Cetil (Lupin)
- Forcef (Aristo), India
- Xylid (Pharmaniaga), Malaysia
- Zinacef, (Glaxo Wellcome), China
- Zinadol, (GlaxoSmithKline), Greece
- Zamur (Mepha)
Indications
As for the other cephalosporins, although as a second-generation it is less susceptible to Beta-lactamase and so may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease.
Side effects
Cefuroxime is generally well tolerated and side effects are usually transient. Cefuroxime, if taken with food, is both better absorbed and less likely to cause its commonest upsets of diarrhea, nausea, vomiting, headaches/migraines, dizziness and abdominal pain.
Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, recent assessments have shown no increased risk for cross-allergy for cefuroxime and several other 2nd generation or later cephalosporins.[3]
References
- ^ Zinnat entry on the Glaxo Smith Kline website.
- ^ Jędrzejczyk, Tadeusz. "Internetowa Encyklopedia Leków". leki.med.pl. Retrieved on 2007-03-03.
- ^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776.
Wikipedia content modification information:
- This page was last modified on 15 August 2008, at 04:53.
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