Chloride potassium symporter 4

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Solute carrier family 12 (potassium/chloride transporters), member 4
Identifiers
Symbols SLC12A4; FLJ40489; KCC1
External IDs OMIM: 604119 MGI: 1309465 HomoloGene: 21056
Orthologs
Human Mouse
Entrez 6560 20498
Ensembl n/a ENSMUSG00000017765
Uniprot n/a Q3TJG5
Refseq NM_005072 (mRNA)
NP_005063 (protein)		 NM_009195 (mRNA)
NP_033221 (protein)
Location n/a Chr 8: 108.83 - 108.86 Mb
Pubmed search [1] [2]


Potassium-chloride transporter, member 4 is a chloride potassium symporter. It is encoded by the gene SLC12A4.[1]

See also

References

  1. ^ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Further reading

  • Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1.". Hum. Mol. Genet. 2 (10): 1589–95. PMID 8268911. 
  • Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.". J. Biol. Chem. 271 (27): 16237–44. PMID 8663127. 
  • Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379. 
  • Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.". Am. J. Physiol. 277 (5 Pt 1): C899–912. PMID 10564083. 
  • Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262. 
  • Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion.". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element.". Blood 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052. 
  • Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cells.". Bioelectrochemistry (Amsterdam, Netherlands) 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

{

v • d • e
Membrane transport protein: ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
ATPase
Other
v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1-10
11-20
21-30
31-40
41-45
O
Other

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  • This page was last modified on 10 July 2008, at 02:43.

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