Chlorothiazide

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Chlorothiazide
Systematic (IUPAC) name
6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Identifiers
CAS number 58-94-6
ATC code C03AA04
PubChem 2720
DrugBank APRD00721
ChemSpider 2619
Chemical data
Formula C7H6ClN3O4S2 
Mol. mass 295.725 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Nil
Half life 45 to 120 minutes
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)
Legal status

℞-only(US)
Routes Oral

Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive.

Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another without risk of toxicity. Because it is absorbed enterically there are no risks associated with chlorothiazide as there are with furosemide administration.

Contents

Indications

Contraindications

Dose

  • 500 mg–1 g once or twice a day, by mouth or through NG tube (reconstituted suspension)
  • May also be given intravenously, and should be given first if given in combination with IV lasix since it potentiate's the diuretic effect of furosemide.

Side effects

v • d • e
Membrane transport modulators
Channel blocker
Amlodipine  • Amrinone  • Anandamide  • Anipamil  • Azimilide  • Bencyclane  • Benidipine  • Bepridil  • Berbamine  • Bevantolol  • Canadine  • Carboxyamido-Triazole  • Cilnidipine  • Cinnarizine  • Clentiazem  • Conotoxins  • Darodipine  • Dauricine  • Devapamil  • Diltiazem  • Dimeditiapramine  • Dotarizine  • Efonidipine  • Emopamil  • Enpiperate  • Eperisone  • Falipamil  • Fantofarone  • Fasudil  • Felodipine  • Fenamic acid  • Fendiline  • Flunarizine  • Fosfedil  • Gabapentin  • Gallopamil  • Isradipine  • Lacidipine  • Lamotrigine  • Lercanidipine  • Lidoflazine  • Magnesium sulfate  • Manidipine  • Manoalide  • Mepirodipine  • Mibefradil  • Monatepil  • Naftopidil  • Nicardipine  • Nifedipine  • Niguldipine  • Niludipin  • Nilvadipine  • Nimodipine  • Nisoldipine  • Nitrendipine  • Norverapamil  • Ochratoxin A  • Octylonium  • Osthol  • Oxodipine  • Perhexiline  • Pinaverium  • Piperidine  • Pranidipine  • Prenylamine  • Risedronic acid  • Ryodipine  • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid  • Tranilast  • Verapamil
Symporter inhibitor
v • d • e
Diuretics (C03)
Low ceiling
Other
High ceiling/
Loop diuretic at AL
Potassium-sparing at CD
Vasopressin antagonists

Wikipedia content modification information:

  • This page was last modified on 1 October 2008, at 02:49.

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