Chlortetracycline

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Chlortetracycline
Systematic (IUPAC) name
(2Z,4S,4aS,5aS,6S,12aS)-2-(amino-hydroxy-
methylidene)-7-chloro-4-dimethylamino-6,10,11,12a-
tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-
1,3,12-trione
Identifiers
CAS number 57-62-5
ATC code D06AA02 A01AB21
PubChem 5280963
Chemical data
Formula C22H23ClN2O8 
Mol. mass 478.879 g/mol
Pharmacokinetic data
Bioavailability 30%
Protein binding 50 to 55%
Metabolism Hepatic (75%)
Half life 5.6 to 9 hours
Excretion Renal and biliary
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes Oral, IV, topical

Chlortetracycline (trade name Aureomycin®, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Duggar in a soil sample from Sanborn Field at the University of Missouri, yielding an actinomycete, Streptomyces aureofaciens (hence the name Aureomycin). In veterinary medicine, it is commonly used to treat conjunctivitis in cats.[1]

References

  1. ^ Merck Veterinary Manual. 
v • d • e
Stomatological preparations (A01)
Caries prophylactic agents
Anti-infectives and antiseptics
Corticosteroids (Glucocorticoids)
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Antibiotics and chemotherapeutics for dermatological use (D06)
Antibiotics
Tetracycline and derivatives
Demeclocycline · Chlortetracycline · Oxytetracycline · Tetracycline
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Chemotherapeutics
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Antibacterials for systemic use: protein synthesis inhibitors (30S) - tetracycline antibiotics (J01A)
Tetracyclines
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Wikipedia content modification information:

  • This page was last modified on 14 May 2008, at 06:34.

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