Chlorzoxazone

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Chlorzoxazone
Systematic (IUPAC) name
5-chloro-3H-benzooxazol-2-one
Identifiers
CAS number 95-25-0
ATC code M03BB03
PubChem 2733
DrugBank APRD00308
ChemSpider 2632
Chemical data
Formula C7H4ClNO2 
Mol. mass 169.565 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability well absorbed
Protein binding 13–18%
Metabolism hepatic
Half life 1.1 hr
Excretion urine (<1%)
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes oral

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Parafon Forte, a combination of chlorzoxazone and acetaminophen. Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction.

External links

  • Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta.". Eur J Pharmacol. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676. 
  • Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.". J Clin Pharmacol 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290. 
  • Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.". J Pharm Pharmacol 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMID 16393464. 
v • d • e
Skeletal Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ blocking)
Curare alkaloids
Centrally acting
Other
Directly acting


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  • This page was last modified on 1 October 2008, at 02:52.

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