Cholesterol 7 alpha-hydroxylase

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cytochrome P450, family 7, subfamily A, polypeptide 1
Identifiers
Symbol CYP7A1
Alt. Symbols CYP7
Entrez 1581
HUGO 2651
OMIM 118455
RefSeq NM_000780
UniProt P22680
Other data
EC number 1.14.13.17
Locus Chr. 8 q11-q12

Cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol.

It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high.[1] The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.

References

  1. ^ Chawla A, Saez E, Evans RM (2000). "Don't know much bile-ology". Cell 103: 1–4. doi:10.1016/S0092-8674(00)00097-0. 

External links

v • d • e
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarate
1.14.13 - NADH or NADPH
1.14.14 - reduced flavin or flavoprotein
1.14.15 - reduced iron-sulfur protein
1.14.16 - reduced pteridine
1.14.17 - reduced ascorbate
1.14.18-19 - other
1.14.99 - miscellaneous
v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1
A1, A2, B1
CYP2
A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3
CYP4
A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20
CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51
CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)
v • d • e
Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes
To HMG-CoA
Ketogenesis
To Mevalonic acid
To DMAPP
To Cholesterols
To Bile acids
Cholesterol 7 alpha-hydroxylase
see also intermediates

Wikipedia content modification information:

  • This page was last modified on 6 June 2008, at 22:47.

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