This MedLibrary.org supplementary page on Cis-regulatory element is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same strand. This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites of one or more trans-acting factors. A cis-element may be located in the promoter region 5' to the gene it controls, in an intron, or in the 3' untranslated region.
In contrast, trans-regulatory elements are species which may modify the expression of genes distant from the gene that was originally transcribed to create them. To demonstrate the concept (this is not a specific example), a transcription factor which regulates a gene on chromosome 6 might itself have been transcribed from a gene on chromosome 11. This term is constructed from the Latin root -trans, which means "across from".
To summarize, cis- elements are present on the same strand as the gene they regulate whereas trans- elements can regulate genes distant from the gene from which they were transcribed.
External references
- Wray, G. A. 2007. The evolutionary significance of cis-regulatory mutations. Nature Reviews Genetics 8, 206-216
- Gompel et al. 2005. Chance caught on the wing: cis regulation evolution and the origin of pigmentation patterns in Drosophila. Nature 433: 481-487.
- Prud'homme et al. 2006. Repeated morphological evolution through cis regulatory changes in a pleiotropic gene. Nature 440: 1050-1053.
- Stern, D.L. 2000. Perspective: Evolutionary developmental biology and the problem of variation. Evolution 54: 1079-1091.
- Carroll, S.B., Grenier, J.K. and Weatherbee, S.D. 2005. "From DNA to diversity: Molecular genetics and the evolution of animal design" Blackwell publishing
See also
DNA
RNA
- Cis-regulatory RNA elements
- SECIS element, mRNA
- Polyadenylation signals, mRNA
- Iron Responsive Element, mRNA
- AU-rich element, mRNA
- Rfam
- Transterm
See also
- Regulation of gene expression
- Cis-acting element
- Gene regulatory network
- Operon
- Promoter
- Trans-acting factor
 |
This genetics article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 28 November 2008, at 16:10.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Cis-regulatory element".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.