Coagulation factor II receptor

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Coagulation factor II (thrombin) receptor
Identifiers
Symbols F2R; CF2R; HTR; PAR1; TR
External IDs OMIM: 187930 MGI: 101802 HomoloGene: 1510
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2149 14062
Ensembl ENSG00000181104 ENSMUSG00000048376
Uniprot P25116 Q3UK34
Refseq NM_001992 (mRNA)
NP_001983 (protein)		 NM_010169 (mRNA)
NP_034299 (protein)
Location Chr 5: 76.05 - 76.07 Mb Chr 13: 96.7 - 96.72 Mb
Pubmed search [1] [2]

Coagulation factor II (thrombin) receptor, also known as F2R or protease activated receptor 1 (PAR1) is a human gene.

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.1

See also

References

  1. ^ "Entrez Gene: F2R coagulation factor II (thrombin) receptor".

Further reading

  • Coughlin SR, Vu TK, Hung DT, Wheaton VI (1992). "Characterization of a functional thrombin receptor. Issues and opportunities.". J. Clin. Invest. 89 (2): 351–5. doi:10.1172/JCI115592. PMID 1310691. 
  • Howell DC, Laurent GJ, Chambers RC (2002). "Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.". Biochem. Soc. Trans. 30 (2): 211–6. doi:10.1042/ (inactive 14 October 2008). PMID 12023853. 
  • Tellez C, Bar-Eli M (2003). "Role and regulation of the thrombin receptor (PAR-1) in human melanoma.". Oncogene 22 (20): 3130–7. doi:10.1038/sj.onc.1206453. PMID 12789289. 
  • Remillard CV, Yuan JX (2005). "PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?". Am. J. Physiol. Lung Cell Mol. Physiol. 288 (5): L789–92. doi:10.1152/ajplung.00016.2005. PMID 15821019. 
  • Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases.". Circulation 114 (10): 1070–7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. 
  • Traynelis SF, Trejo J (2007). "Protease-activated receptor signaling: new roles and regulatory mechanisms.". Curr. Opin. Hematol. 14 (3): 230–5. doi:10.1097/MOH.0b013e3280dce568. PMID 17414212. 
  • Vu TK, Hung DT, Wheaton VI, Coughlin SR (1991). "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.". Cell 64 (6): 1057–68. doi:10.1016/0092-8674(91)90261-V. PMID 1672265. 
  • Wojtukiewicz MZ, Tang DG, Ben-Josef E, et al. (1995). "Solid tumor cells express functional "tethered ligand" thrombin receptor.". Cancer Res. 55 (3): 698–704. PMID 7834643. 
  • Hein L, Ishii K, Coughlin SR, Kobilka BK (1994). "Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.". J. Biol. Chem. 269 (44): 27719–26. PMID 7961693. 
  • Mathews II, Padmanabhan KP, Ganesh V, et al. (1994). "Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.". Biochemistry 33 (11): 3266–79. doi:10.1021/bi00177a018. PMID 8136362. 
  • Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.". Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504–8. doi:10.1073/pnas.91.2.504. PMID 8290554. 
  • Hoffman M, Church FC (1993). "Response of blood leukocytes to thrombin receptor peptides.". J. Leukoc. Biol. 54 (2): 145–51. PMID 8395550. 
  • Bahou WF, Nierman WC, Durkin AS, et al. (1993). "Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5.". Blood 82 (5): 1532–7. PMID 8395910. 
  • Schmidt VA, Vitale E, Bahou WF (1996). "Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene.". J. Biol. Chem. 271 (16): 9307–12. doi:10.1074/jbc.271.16.9809. PMID 8621593. 
  • Li F, Baykal D, Horaist C, et al. (1996). "Cloning and identification of regulatory sequences of the human thrombin receptor gene.". J. Biol. Chem. 271 (42): 26320–8. doi:10.1074/jbc.271.42.26320. PMID 8824285. 
  • Shapiro MJ, Trejo J, Zeng D, Coughlin SR (1997). "Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.". J. Biol. Chem. 271 (51): 32874–80. doi:10.1074/jbc.271.51.32874. PMID 8955127. 
  • Ogino Y, Tanaka K, Shimizu N (1997). "Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.". Eur. J. Pharmacol. 316 (1): 105–9. doi:10.1016/S0014-2999(96)00653-X. PMID 8982657. 
  • Molino M, Bainton DF, Hoxie JA, et al. (1997). "Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation.". J. Biol. Chem. 272 (9): 6011–7. doi:10.1074/jbc.272.9.6011. PMID 9038223. 
  • Renesto P, Si-Tahar M, Moniatte M, et al. (1997). "Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor.". Blood 89 (6): 1944–53. PMID 9058715. 

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP, EP (1, 2, 3, 4), PGF) • Prostacyclin • Thromboxane
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotensin (1, 2)
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172A, 173, 174, 176, 177, 182)
Adenosine (A1, A2a, A2b, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) • Adrenomedullin • Anaphylatoxin (C3a, C5a) • Angiotensin (1, 2) • Apelin • Bile acid • Bombesin (BRS3, GRPR, NMBR) • Bradykinin (B1, B2) • Cannabinoid (CB1, CB2) • Chemokine • Cholecystokinin (A, B) • Dopamine (D1, D2, D3, D4, D5) • EBI2 • Endothelin (A, B) • Estrogen • Formyl peptide (1, L1, L2) • Free fatty acid (1, 2, 3, 4) • FSH • Galanin (1, 2, 3) • Gonadotropin-releasing hormone (1, 2) • Ghrelin • Histamine (H1, H2, H3, H4) • Kisspeptin • Luteinizing hormone/choriogonadotropin • Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanocortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Melatonin (1A, 1B) • Motilin • Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) • Olfactory • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Orexin (1, 2) • Oxytocin • Oxoglutarate • PAF • Prokineticin (1, 2) • Prolactin-releasing peptide • Protease-activated (1, 2, 3, 4) • Relaxin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • SREB • Succinate • TAAR (1, 2, 3, 5, 6, 8, 9) • Tachykinin (1, 2, 3) • Thyrotropin • Thyrotropin-releasing hormone • Urotensin-II • Vasopressin (1A, 1B, 2)
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
Other
Calcium-sensing receptor • GABA B (1, 2) • Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) • Smoothened

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