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| Cartoon diagram of pig colipase (blue) in complex with human pancreatic lipase and a small molecule inhibitor. From PDB 1LPB. | |
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colipase, pancreatic
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| Identifiers | |
| Symbol | CLPS |
| Entrez | 1208 |
| HUGO | 2085 |
| OMIM | 120105 |
| RefSeq | NM_001832 |
| UniProt | P04118 |
| Other data | |
| Locus | Chr. 6 pter-p21.1 |
Colipase is a protein co-factor required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.
Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
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Wikipedia content modification information:
- This page was last modified on 21 June 2008, at 17:29.
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