Cytochrome P450 14α-demethylase

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cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
Symbol CYP51A1
Alt. Symbols CYP51
Entrez 1595
HUGO 2649
OMIM 601637
RefSeq NM_000786
UniProt Q16850
Other data
EC number 1.14.13.70
Locus Chr. 7 q21.2-21.3

CYP51A1 (or lanosterol 14 alpha-demethylase) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) which converts lanosterol to cholesterol.

It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.[1]

Lanosterol

Ergosterol

Cholesterol

See also

References

  1. ^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). "Antifungal drug resistance in pathogenic fungi". Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500. 

External links

 This oxidoreductase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes
To HMG-CoA
Ketogenesis
To Mevalonic acid
To DMAPP
To Cholesterols
To Bile acids
see also intermediates
v • d • e
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarate
1.14.13 - NADH or NADPH
1.14.14 - reduced flavin or flavoprotein
1.14.15 - reduced iron-sulfur protein
1.14.16 - reduced pteridine
1.14.17 - reduced ascorbate
1.14.18-19 - other
1.14.99 - miscellaneous
v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1
A1, A2, B1
CYP2
A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3
CYP4
A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20
CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51
CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

Wikipedia content modification information:

  • This page was last modified on 9 July 2008, at 18:07.

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