D-amino acid dehydrogenase

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D-amino-acid dehydrogenase (EC 1.4.99.1) is a bacterial enzyme that catalyses the oxidation of D-amino acids into their corresponding oxoacids. It contains both flavin and nonheme iron as cofactors.[1] The enzyme has a very broad specificity and can act on most D-amino acids.[2]

D-amino acid + H2O + acceptor <=> a 2-oxo acid + NH3 + reduced acceptor

This reaction is distinct from the oxidation reaction catalysed by D-amino acid oxidase that uses oxygen as a second substrate, as the dehydrogenase can use many different compounds as electron acceptors, with the physiological substrate being coenzyme Q.[1][3]

See also

References

  1. ^ a b Olsiewski PJ, Kaczorowski GJ, Walsh C (1980). "Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B". J. Biol. Chem. 255 (10): 4487–94. PMID 6102989. 
  2. ^ Tsukada K (1966). "D-amino acid dehydrogenases of Pseudomonas fluorescens". J. Biol. Chem. 241 (19): 4522–8. PMID 5925166. 
  3. ^ Jones H, Venables WA (1983). "Effects of solubilisation on some properties of the membrane-bound respiratory enzyme D-amino acid dehydrogenase of Escherichia coli". FEBS Lett. 151 (2): 189–92. doi:10.1016/0014-5793(83)80066-0. PMID 6131836. 

External links

v • d • e
CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1 - NAD/NADP acceptor
1.4.3 - oxygen acceptor
1.4.4 - disulfide acceptor
1.4.99 - other acceptors
D-amino acid dehydrogenase - Amine dehydrogenase
v • d • e
Mitochondrial electron transport chain/oxidative phosphorylation
Primary
Other
v • d • e
Cellular Respiration
Aerobic Respiration
Anaerobic Respiration
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  • This page was last modified on 9 June 2008, at 12:03.

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