Dermatan sulfate

This MedLibrary.org supplementary page on Dermatan sulfate is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources.

Contents

Function

Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.

Pathology

Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.

An excess of Dermatan Sulfate in the Mitral Valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, Mitral Valve Prolapse (into the Left Ventricle) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification and eccentric (volume dependent or dilated) hypertrophy and eventually Left Heart failure if untreated. Also used to treat sun burns.

See also

External links

References

  1. ^ Trowbridge, JM; Gallo, RL (2002 Sep). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–25R. doi:10.1093/glycob/cwf066. PMID 12213784. 
 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists
Heparin group
Glycoprotein IIb/IIIa inhibitors
Other platelet
aggregation inhibitors
Enzymes
Direct thrombin inhibitors
Other antithrombotics
Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Ozagrel • Ramatroban • Rivaroxaban
Non-medicinal
v • d • e
Polysaccharides: glycosaminoglycans
Unsulfated, extracellular
Sulfated, extracellular
Sulfated, intracellular

Wikipedia content modification information:

  • This page was last modified on 28 May 2008, at 16:42.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Dermatan sulfate".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.