Dextrothyroxine

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 It has been suggested that levothyroxine be merged into this article or section. ()
Thyroxine
Identifiers
CAS number [7488-70-2]
PubChem 853
MeSH Thyroxine
SMILES
 
Properties
Molecular formula C15H11I4NO4
Molar mass 776.87
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Thyroxine, or 3,5,3',5'-tetra­iodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland.

T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.

Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2] The half-life of thyroxine once released into the blood circulatory system is about 1 week.

The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.

Reactions

Transformations
Transformations

References

  1. ^ MeSH Dextrothyroxine
  2. ^ C10AX01
v • d • e
Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones)
Hypothalamic-pituitary
Adrenal axis
Thyroid axis
Gonadal axis
Other end. glands
Non-end. glands
Target-derived

Wikipedia content modification information:

  • This page was last modified on 19 May 2008, at 12:37.

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