Diazoxide

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Diazoxide
Systematic (IUPAC) name
7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
Identifiers
CAS number 364-98-7
ATC code C02DA01 V03AH01
PubChem 3019
DrugBank APRD00914
Chemical data
Formula C8H7ClN2O2S 
Mol. mass 230.672 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90%
Metabolism Hepatic oxidation and sulfate conjugation
Half life 21-45 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)
Legal status

POM(UK) ℞-only(US)
Routes Oral, intravenous

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)
Vasodilators
Other antihypertensives
Low ceiling diuretics
High ceiling diuretics
Potassium-sparing diuretics

Wikipedia content modification information:

  • This page was last modified on 6 April 2008, at 15:07.

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