Dicumarol

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Dicoumarol
Systematic (IUPAC) name
3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)
Identifiers
CAS number 66-76-2
ATC code B01AA01
PubChem 653
DrugBank APRD00761
Chemical data
Formula C19H12O6 
Mol. mass 336.295 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding plasmatic proteins
Metabolism hepatic
Half life  ?
Excretion faeces, urine
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Dicoumarol (INN) or dicumarol (USAN) is an anticoagulant that functions as a Vitamin K antagonist (similar to warfarin). It is also used in biochemical experiments as an inhibitor of reductases.

It is a derivative of coumarin.

External links

  • DDB 30166
  • Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L (2003). "Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.". Cancer Res 63 (17): 5513–20. PMID 14500388. 
  • Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A (2004). "Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport.". Eur J Cell Biol 83 (6): 263–79. doi:10.1078/0171-9335-00377. PMID 15511084. 
  • Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L (2005). "Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.". Arch Biochem Biophys 434 (2): 241–7. doi:10.1016/j.abb.2004.11.002. PMID 15639223. 
  • Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E (2003). "Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride.". Pharm Res 20 (7): 1093–100. doi:10.1023/A:1024474609667. PMID 12880296. 
v • d • e
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists
Heparin group
Glycoprotein IIb/IIIa inhibitors
Other platelet
aggregation inhibitors
Enzymes
Direct thrombin inhibitors
Other antithrombotics
Non-medicinal
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Wikipedia content modification information:

  • This page was last modified on 18 June 2008, at 15:26.

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