Disopyramide

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Disopyramide
Systematic (IUPAC) name
4-dipropan-2-ylamino-2-phenyl-2-pyridin-2-yl-butanamide
Identifiers
CAS number 3737-09-5
ATC code C01BA03
PubChem 3114
DrugBank APRD00507
Chemical data
Formula C21H29N3O 
Mol. mass 339.475 g/mol
Pharmacokinetic data
Bioavailability High
Protein binding 50% to 65%
(concentration-dependent)
Metabolism Hepatic (CYP3A4-mediated)
Half life 6.7 hours (range 4 to 10 hours)
Excretion Renal (80%)
Therapeutic considerations
Pregnancy cat.

B2(AU) C(US)
Legal status

POM(UK) ℞-only(US)
Routes Oral, intravenous

Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

Cardiac Adverse Effects

Extracardiac Effects

External links

v • d • e
Antiarrhythmic agents (C01B)
class I
(sodium channel)
class Ia
Ajmaline • Disopyramide • Prajmaline • Procainamide • Quinidine • Sparteine
class Ib
class Ic
class II
(beta blockers)
class III
(potassium channel)
class IV
(calcium channel blockers)
class V
(other)
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 28 April 2008, at 15:47.

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