Dombrock antigen system

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ADP-ribosyltransferase 4 (Dombrock blood group)
Identifiers
Symbols ART4; CD297; DO; DOK1
External IDs OMIM: 110600 MGI: 1202710 HomoloGene: 10883
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 420 109978
Ensembl ENSG00000111339 ENSMUSG00000030217
Uniprot Q93070 n/a
Refseq NM_021071 (mRNA)
NP_066549 (protein)		 NM_026639 (mRNA)
NP_080915 (protein)
Location Chr 12: 14.87 - 14.89 Mb Chr 6: 136.81 - 136.82 Mb
Pubmed search [1] [2]

ADP-ribosyltransferase 4 (Dombrock blood group), also known as ART4, is a human gene.[1] ART4 has also been designated as CD297 (cluster of differentiation 297).

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[1]

References

  1. ^ a b "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)".

Further reading

  • Reid ME (2003). "The Dombrock blood group system: a review.". Transfusion 43 (1): 107–14. PMID 12519438. 
  • Tippett P (1967). "Genetics of the Dombrock blood group system.". J. Med. Genet. 4 (1): 7–11. PMID 6034522. 
  • Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p.". Hum. Genet. 98 (5): 518–21. PMID 8882867. 
  • Koch-Nolte F, Haag F, Braren R, et al. (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.". Genomics 39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID 9119374. 
  • Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2.". Vox Sang. 79 (1): 53–6. PMID 10971215. 
  • Gubin AN, Njoroge JM, Wojda U, et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.". Blood 96 (7): 2621–7. PMID 11001920. 
  • Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.". Vox Sang. 81 (1): 49–51. PMID 11520417. 
  • Rios M, Hue-Roye K, Øyen R, et al. (2002). "Insights into the Holley- and Joseph- phenotypes.". Transfusion 42 (1): 52–8. PMID 11896313. 
  • Rios M, Storry JR, Hue-Roye K, et al. (2002). "Two new molecular bases for the Dombrock null phenotype.". Br. J. Haematol. 117 (3): 765–7. PMID 12028057. 
  • Glowacki G, Braren R, Firner K, et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.". Protein Sci. 11 (7): 1657–70. PMID 12070318. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements.". Biochim. Biophys. Acta 1730 (3): 173–86. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404. 

External links


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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350

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