Dopamine beta hydroxylase

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Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Identifiers
Symbols DBH; DBM
External IDs OMIM: 609312 MGI: 94864 HomoloGene: 615
EC number 1.14.17.1
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1621 13166
Ensembl ENSG00000123454 ENSMUSG00000000889
Uniprot P09172 Q3V1U4
Refseq NM_000787 (mRNA)
NP_000778 (protein)		 NM_138942 (mRNA)
NP_620392 (protein)
Location Chr 9: 135.49 - 135.51 Mb Chr 2: 26.99 - 27 Mb
Pubmed search [1] [2]

Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine: Synonyms: Aromatic L-amino acid decarboxylase (EC 4.1.1.28, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) is a lyase enzyme.

Dopamine

Norepinephrine. Note extra hydroxyl group.

DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. [1] It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.

DBH is inhibited by disulfiram, [2] tropolone, [3] and, most selectively, by nepicastat. [4]

See also

References

  1. ^ Rush RA, Geffen LB (1980). "Dopamine beta-hydroxylase in health and disease.". Crit Rev Clin Lab Sci. 12 (3): 241–77. doi:10.3109/10408368009108731. PMID 6998654. 
  2. ^ Goldstein M, Anagnoste B, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by Disulfiram.". Life Sci 3: 763–7. doi:10.1016/0024-3205(64)90031-1. PMID 14203977. 
  3. ^ Goldstein M, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by tropolone and other chelating agents.". Biochem Pharmacol 13: 1103–6. doi:10.1016/0006-2952(64)90109-1. PMID 14201135. 
  4. ^ Stanley WC et al. (1997). "Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.". British Journal of Pharmacology 121 (8): 1803–9. doi:10.1038/sj.bjp.0701315. PMID 9283721. 

External links

 This oxidoreductase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarate
1.14.13 - NADH or NADPH
1.14.14 - reduced flavin or flavoprotein
1.14.15 - reduced iron-sulfur protein
1.14.16 - reduced pteridine
1.14.17 - reduced ascorbate
Dopamine beta hydroxylase
1.14.18-19 - other
1.14.99 - miscellaneous
v • d • e
Metabolism: amino acid metabolism - neurotransmitter enzymes
histidine→histamine
tyrosine→dopamine→epinephrine
glutamate→GABA
tryptophan→serotonin→melatonin
arginine→NO
choline→Acetylcholine
see also intermediates


Wikipedia content modification information:

  • This page was last modified on 8 October 2008, at 01:19.

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