Dopexamine

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Dopexamine
Systematic (IUPAC) name
4-[2-[6-(phenethylamino)hexylamino]ethyl]benzene-1,2-diol
Identifiers
CAS number 86197-47-9
ATC code C01CA14
PubChem 55483
Chemical data
Formula C22H32N2O2 
Mol. mass 429.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Dopexamine is a β2-adrenergic receptor agonist. It also acts at dopamine receptors.[1]

Use in sepsis has been proposed.[2]

It is considered a inotropic agent.[3]

References

  1. ^ Brown RA, Dixon J, Farmer JB, et al (July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". Br. J. Pharmacol. 85 (3): 599–608. PMID 2862944. 
  2. ^ Birnbaum J, Klotz E, Spies CD, et al (2006). "Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats". Crit Care 10 (4): R117. doi:10.1186/cc5011. PMID 16893450. PMC:1750974. 
  3. ^ Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?". Chest 123 (5 Suppl): 460S–3S. PMID 12740229. 
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Cardiac stimulants excluding cardiac glycosides (C01C)
Adrenergic and
dopaminergic agents
α
β
mixed
Both
DOPAMINE • Dopexamine • Ibopamine • Octopamine
Unknown/ungrouped
Phosphodiesterase inhibitors (PDE3I)
Other cardiac stimulants

Wikipedia content modification information:

  • This page was last modified on 10 July 2008, at 04:40.

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